Expression Pattern and Clinical Significance of E2F Transcription Factors in Skin Cutaneous Melanoma
نویسندگان
چکیده
Introduction: E2F is a group of genes that encodes family transcription factors in higher eukaryotes. Although emerging evidence indicates E2Fs are implicated various cancer types, the diverse expression patterns and prognostic values SKCM have yet to be elucidated. The purpose this study was enhance our knowledge concerning role patients.. Methods: GEPIA, Human Protein Atlas, TIMER, cBioPortal, GeneMANIA, DAVID 6.8 KEGG PATHWAY Database were utilized study.
منابع مشابه
Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer
Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer. Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and ...
متن کاملStudy of Expression Pattern of Some Transcription Factors in Wheat under Drought Stress and Zinc Nanoparticles
Under drought stress condition, the signaling system induces expression of certain genes to counteract the deleterious effects of environmental stress. Among the essential micronutrients for plant growth and development, zinc has an important role in many plant metabolic processes including gene expression and stress tolerance. In order to investigate the effect of drought stress and ZnO on r...
متن کاملPrognostic significance of nuclear ING3 expression in human cutaneous melanoma.
PURPOSE The novel tumor-suppressor ING3 has been shown to modulate transcription, cell cycle control, and apoptosis. Our previous study showed that ING3 promotes UV-induced apoptosis via the Fas/caspase-8-dependent pathway in melanoma cells. To investigate the putative role of ING3 in the development of melanoma, we examined the expression of ING3 in melanocytic lesions at different stages and ...
متن کاملEvaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma
Background and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related stained slides were reviewed by two pathologists. The re...
متن کاملSignificance of vascular endothelial growth factor expression in skin melanoma.
BACKGROUND/AIM Melanoma is a heterogeneous disease of skin and mucous membranes which shows significant increase in incidence worldwide in the past decades. In the process of forming new blood vessels stimulators of angiogenesis participate. There is an increase production of vascular endothelial growth factor (VEGF-C and VEGF-D), which expression cause change of endothelial cells, and higher d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of women's health and development
سال: 2023
ISSN: ['2644-2884']
DOI: https://doi.org/10.26502/fjwhd.2644-288400104